Native™ Shark Antibody Discovery Service
Creative Biolabs offers native shark monoclonal antibody development for global clients through our unique Native™ shark antibody discovery service.
Sharks, and other members in Chondrichthyes, are currently recognized as the most evolutionarily ancient animals that rely on antibodies as part of their adaptive immune system. Interestingly, apart from the expected IgM and IgW, cartilaginous fishes also produce a type of ancestral antibody referred to immunoglobulin new antigen receptor (IgNAR). IgNAR is quite unconventional antibody composed of only a homodimeric heavy chain which contains one variable and five constant domains for each chain (Fig. 1). Owe to the distinct structure between shark and human antibody domains, the extremely high stability of IgNAR has been presented. In addition, VNAR is around 10 times smaller than standard antibodies and able to continue to function and exist within very extreme conditions. These properties allow IgNAR to play a potential role in pharmaceutical application. They can easily get into certain spots that regular size antibodies cannot, such as small gaps and nooks in cancer cells. Moreover, the variable domain of IgNAR can also be developed as single domain antibodies.
Single domain antibody (sdAbs) is the single monomeric variable domain of a whole antibody which can also bind to a specific antigen selectively. The first single domain antibody was actually engineered from VHH fragments of camel heavy-chain antibodies. It is also available to engineer single domain antibodies from the VNAR fragments of cartilaginous fishes heavy-chain antibodies. Compared with common antibodies (150-160 kDa) and other engineered antibody fragments, such as Fab (~50 kDa) and scFv (~25 kDa), single domain antibodies have much smaller molecular weight of only 12-15 kDa. This property enable single domain antibody to penetrate tissues easier in vivo to improve bioavailability for pharmaceutical applications.
With years of research and development experience in antibody discovery, scientists of Creative Biolabs have developed the Native™ Antibody Discovery Platform to generate monoclonal antibody with native and in vivo characteristics. This proprietary platform takes advantage of the antigen-specific B lymphocytes cytometry technology, and can ideally generate large scale of candidate shark antibodies in one step. Moreover, these shark antibodies are all composed of native paired heavy-chains and light-chains (for IgM and IgW) or just heavy-chains (for IgNAR), and have already gone through the in vivo affinity maturation. Thus, our Native™ shark monoclonal antibody will possess higher specificity and affinity than those produced by other techniques and will be intrinsically more appropriate for the development of single domain antibody or other research objectives.
Creative Biolabs has been a long-term expert in the field of antibody discovery and manufacturing. Our scientists take pride in having earned great reputation from our global clients by satisfactorily completed thousands of relevant projects in the past decade. We are therefore confident in offering the best and most suitable service for our customer to meet each of their specific demands.
Fig.1 Comparison between mouse/human IgG and shark IgNAR. (Stanfield et al. 2004)
- Stanfield, R. L., Dooley, H., Flajnik, M. F. and Wilson, I. A. (2004) ‘Crystal structure of a shark single-domain antibody V region in complex with lysozyme’, Science, 305(5691), 1770-1773.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
[NEW] About Us – Lignar Engineering | ignar – Vietnamnhanvan
For more than 3 decades, reputable woodworking, fibre cement, mineral wool, and paper companies in South East Asia have chosen Lignar as their primary partner in developing maximum performance turnkey solutions for dust extraction. Amongst them are Enlighten Furniture Decoration Co. from Singapore, Chea-Ee Industries from Malaysia, and Lacquer Craft Mfg. Co. from China.
Customers highly regard Lignar for its commitment to ensure zero-downtime. By bearing the symbol of Lignar within your manufacturing process, it is a testimony of Lignar’s reliability, professionalism, and customer-focus. The symbol personifies high productivity of your production facility with a safer working environment.
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Customers always choose Lignar because of the value it creates for them. Its customers’ profitability is improved by gaining higher energy and cost savings, and optimal manufacturing performance with great consistency through its innovative and well-integrated dust control systems.
Widely recognised for its specialised expertise in dust control systems integration, Lignar is established in 1982 to enable peak performance in manufacturing by providing customers with end-to-end dust control solutions – from the designing and manufacturing of dust control equipment, to its integration, commissioning, and maintenance.For more than 3 decades, reputable woodworking, fibre cement, mineral wool, and paper companies in South East Asia have chosen Lignar as their primary partner in developing maximum performance turnkey solutions for dust extraction. Amongst them are Enlighten Furniture Decoration Co. from Singapore, Chea-Ee Industries from Malaysia, and Lacquer Craft Mfg. Co. from China. Customers highly regard Lignar for its commitment to ensure zero-downtime. By bearing the symbol of Lignar within your manufacturing process, it is a testimony of Lignar’s reliability, professionalism, and customer-focus. The symbol personifies high productivity of your production facility with a safer working environment. Time and again, customers are assured of Lignar’s high quality performance and stable, reliable, and energy-efficient dust control systems through its proprietary methods in systems design, dust control mechanisms of modular bag filters, bag filters, fans, cyclones, and silo discharge systems. Its knowledgeable and dedicated team also gives customers a peace of mind: that their production processes will always run smoothly. Customers always choose Lignar because of the value it creates for them. Its customers’ profitability is improved by gaining higher energy and cost savings, and optimal manufacturing performance with great consistency through its innovative and well-integrated dust control systems.
Best Of Ambition – The World Champion | League Of Legends
Best Of Ambition; A Funny Montage of SSG Ambition featuring his best plays and funniest moments!
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SKT (Faker Taliyah) VS MSF (IgNar Leona) Game 3 Highlights – 2017 World Championship Quarterfinals
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[WR] 🔥 Venom VS Igniter – Comparison | War Robots
Hello to every fellow commander and thanks for tuning in!
In this video I will be presenting preview comparison between the new weapon Venom and Igniter. Hope you enjoy!
00:00 Intro \u0026 Comparison details
01:10 Venom VS Igniter | 200m
03:07 End results: Graphical data
03:35 Venom Typhon Gameplay
An acid launcher that damages enemy robots with a stream of highly corrosive liquid that eats away at armor. Each hit inflicts a powerful DoT effect.
Damage per particle — 278
Patorn: JT Ser
Monthly members: Ramanakumar Vavilla, M Sarepta
➤ CPU: Intel® Core™ i710700K Processor (Overclocked to 5.1 GHz)
➤ GPU: MSI Gaming GeForce RTX 2070 Super 8GB GDRR6 256bit
➤ RAM: G.SKILL TridentZ RGB Series 32GB (4 x 8GB)
➤ SSD: XPG S40G 512GB RGB 3D NAND PCIe Gen3x4 NVMe 1.3 M.2 2280 Internal SSD
➤ HDD: Seagate BarraCuda 2TB Internal Hard Drive HDD
➤ CPU Cooler: ASUS ROG Strix LC 360 RGB White Edition Allinone Liquid CPU Cooler
➤ PSU: Cooler Master 80+ 750 Watt
➤ Motherboard: MSI Z490A PRO ProSeries ATX
➤ Microphone: Blue Snowball iCE USB Mic
Secondary System: Lenovo Legion 5
Ryzen R5 5600H, RTX 3060 (115130Wh), 16gb RAM
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Warrobots Venom Igniter
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